Book
Park, S., Chen, Y., Mechanics of Biological Systems: Introduction to Mechanobiology and Experimental Techniques. Morgan & Claypool Publishers. https://iopscience.iop.org/book/978-1-64327-392-1
Peer-Reviewed Journal
Lee, S. S., Sweren, E., Dare, E., Derr, P., Derr, K., Wang, C. C., Hardesty, B., Willis, A. A., Chen, J., Vuillier, J. K., Du, J., Wool, J., Ruci, A., Wang, V. Y., Lee, C., Iyengar, S., Asami, S., Daskam, M., Lee, C., Lee, J. C., Cho, D., Kim, J., Martinez-Peña, E. G., Lee, S. M., He, X., Wakeman, M., Sicilia, I., Dobbs, D. T., van Ee, A., Li, A., Xue, Y., Williams, K. L., Kirby, C. S., Kim, D., Kim, S., Xu, L., Wang, R., Ferrer, M., Chen, Y., Kang, J. U., Kalhor, R., Kang, S. & Garza, L. A. The use of ectopic volar fibroblasts to modify skin identity. (2024) Science 385, 1047. https://doi.org/10.1126/science.adi1650
Liu, Z., Li, S., Anantha, P., Thanakornsombut, T., Wu, L., Chen, J., Tsuchiya, R., Tripathi, A. K., Chen, Y.* & Barman, I.* Plasmodium sporozoite shows distinct motility patterns in responses to three-dimensional environments. (2024) iScience 27, 110463. https://doi.org/10.1016/j.isci.2024.110463
Kaiyrbekov, K., Endresen, K., Sullivan, K., Zheng, Z., Chen, Y., Serra, F. & Camley, B. A. Migration and division in cell monolayers on substrates with topological defects. (2023) Proc. Natl. Acad. Sci. 120. https://doi.org/10.1073/pnas.2301197120
Liang, L., Zheng, P., Jia, S., Ray, K., Chen, Y. & Barman, I. Plasmonic Nanodiamonds. (2023) Nano Lett. 23, 5746. https://doi.org/10.1021/acs.nanolett.3c01514
Adler, F. R., Anderson, A. R. A., Bhushan, A., Bogdan, P., Bravo-Cordero, J. J., Brock, A., Chen, Y., Cukierman, E., DelGiorno, K. E., Denis, G. V., Ferrall-Fairbanks, M. C., Gartner, Z. J., Germain, R. N., Gordon, D. M., Hunter, G., Jolly, M. K., Karacosta, L. G., Mythreye, K., Katira, P., Kulkarni, R. P., Kutys, M. L., Lander, A. D., Laughney, A. M., Levine, H., Lou, E., Lowenstein, P. R., Masters, K. S., Pe’er, D., Peyton, S. R., Platt, M. O., Purvis, J. E., Quon, G., Richer, J. K., Riddle, N. C., Rodriguez, A., Snyder, J. C., Lee Szeto, G., Tomlin, C. J., Yanai, I., Zervantonakis, I. K. & Dueck, H. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. (2023) Cell Systems 14, 252. https://doi.org/10.1016/j.cels.2023.03.002
Chen, J., Yan, D. & Chen, Y. Understanding the Driving Force for Cell Migration Plasticity. (2023) Biophys. J. https://doi.org/10.1016/j.bpj.2023.04.008
Park, S. & Chen, Y. Measurement of Forces for Trans-Endocytosis at Dorsal and Ventral Sides of the Cell. (2023). The Immune Synapse: Methods and Protocols. 327, https://doi.org/110.1007/978-1-0716-3135-5_21
Pittman, M., Ali, A. M., & Chen, Y.. How sticky? How tight? How hot? (2022) Imaging probes for fluid viscosity, membrane tension and temperature measurements at the cellular level. The International Journal of Biochemistry & Cell Biology, 106329. https://doi.org/10.1016/j.biocel.2022.106329
Afthinos, A., Bera, K., Chen, J., Ozcelikkale, A., Amitrano, A., Choudhury, M. I., Huang, R., Pachidis, P., Mistriotis, P., Chen, Y.* & Konstantopoulos, K.* (2022) Migration and 3D Traction Force Measurements inside Compliant Microchannels. Nano Lett. 22(18), 7318 https://doi.org/10.1021/acs.nanolett.2c01261
Huang, P., Illei, P. B., Franklin, W., Wu, P.-H., Forde, P. M., Ashrafinia, S., Hu, C., Khan, H., Vadvala, H. V., Shih, I.-M., Battafarano, R. J., Jacobs, M. A., Kong, X., Lewis, J., Yan, R., Chen, Y., Housseau, F., Rahmim, A., Fishman, E. K., Ettinger, D. S., Pienta, K. J., Wirtz, D., Brock, M. V., Lam, S. & Gabrielson, E. (2022) Lung Cancer Recurrence Risk Prediction through Integrated Deep Learning Evaluation. Cancers . 14, 4150 https://doi.org/10.3390/cancers14174150
Flournoy, J., Ashkanani, S. & Chen, Y. (2022). Mechanical regulation of signal transduction in angiogenesis. Front. Cell Dev. Biol. 10 https://doi.org/10.3389/fcell.2022.933474
Pittman, M., Iu, E., Li, K., Wang, M., Chen, J., Taneja, N., Jo, M.H., Park, S., Jung, W-.H., Liang, L., Barman, I., Ha, T., Gaitanaros, S., Liu, J. , Burnette, D., Plotnikov, S. Chen, Y. (2022) Membrane Ruffling is a Mechanosensor of Extracellular Fluid Viscosity. Nature Physics. 18(9), 1112 https://doi.org/10.1038/s41567-022-01676-y
Chen, J. & Chen, Y. (2021) Parametric comparison between sparsity-based and deep learning-based image reconstruction of super-resolution fluorescence microscopy. Biomed. Opt. Express. 12, 5246. https://doi.org/10.1364/BOE.427989
Park, Y., Jung, J.-G., Yu, Z.-C., Asaka, R., Shen, W., Wang, Y., Jung, W.-H., Tomaszewski, A., Shimberg, G., Chen, Y., Parimi, V., Gaillard, S., Shih, I.-M. & Wang, T.-L. (2021) A Novel Human Endometrial Epithelial Cell Line for Modeling Gynecological Diseases and for Drug Screening. Lab. Investig. https://doi.org/10.1038/s41374-021-00624-3
Paria, D., Convertino, A., Raj, P., Glunde, K., Chen, Y. & Barman, I. (2021) Nanowire Assisted Mechanotyping of Cellular Metastatic Potential. Adv. Funct. Mater. 2101638 https://doi.org/10.1002/adfm.202101638
Wang, G., Sweren, E., Liu, H., Wier, E., Alphonse, M. P., Chen, R., Islam, N., Li, A., Xue, Y., Chen, J., Park, S., Chen, Y., Lee, S., Wang, Y., Wang, S., Archer, N. K., Andrews, W., Kane, M. A., Dare, E., Reddy, S. K., Hu, Z., Grice, E. A., Miller, L. S. & Garza, L. A. (2021) Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe. 29, 777 https://doi.org/10.1016/j.chom.2021.03.003
Lui, C., Chin, A. F., Park, S., Yeung, E., Kwon, C., Tomaselli, G., Chen, Y. & Hibino, N. (2021) Mechanical Stimulation Enhances Development of Scaffold‐Free, 3D‐Printed, Engineered Heart Tissue Grafts. J. Tissue Eng. Regen. Med. term.3188. https://doi.org/10.1002/term.3188
Endresen, K. D., Kim, M., Pittman, M., Chen, Y. & Serra, F. (2021) Topological defects of integer charge in cell monolayers. Soft Matter. 17, 5878 https://doi.org/10.1039/D1SM00100K
Jung, W.-H., Chen, E., Veneziano, R., Gaitanaros, S.*, Chen, Y.* (2020) Stretching DNA Origami: Effect of Nicks and Holliday Junctions on the Axial Stiffness. Nucleic Acids Research. 48(21):12407 https://doi.org/10.1093/nar/gkaa985
Park, S.#, Jung, W.-H. #, Pittman, M. #, Chen, J. & Chen, Y. (2020) The Effects of Stiffness, Viscosity, and Geometry of Microenvironment in Homeostasis, Aging and Diseases. J. Biomech. Eng. 142, 10 https://doi.org/10.1115/1.4048110
Park, S., Shi, Y., Kim, B. C., Jo, M. H., Cruz, L. O., Gou, Z., Ha, T., Lu, L.-F., Reich, D. H. & Chen, Y. (2020) Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation. Biosens. Bioelectron. 112389. https://doi.org/10.1016/j.bios.2020.112389
Liu, Z., Lee, S. J., Park, S., Konstantopoulos, K., Glunde, K., Chen, Y. * & Barman, I. * (2020) Cancer cells display increased migration and deformability in pace with metastatic progression. FASEB J. 34, 9307 https://doi.org/10.1096/fj.202000101RR
Orrego, S., Chen, Z., Krekora, U., Hou, D., Jeon. S.-Y., Montoya, C. , Chen, Y., Kang, S. H. (2020) Bioinspired Materials with Self-Adaptable Mechanical Properties. Advanced Materials. 32, 1906970 . https://doi.org/10.1002/adma.201906970
Jung, W.-H., Yam, N., Chen, C.-C., Elawad, K., Hu, B. Chen, Y. (2020) Force-Dependent Extracellular Matrix Remodeling by Early-Stage Cancer Cells Alters Diffusion and Induces Carcinoma-Associated Fibroblasts. Biomaterials. 234, 119756 . https://doi.org/10.1016/j.biomaterials.2020.119756
Pitaktong, I., Lui, C., Lowenthal, J., Mattson, G., Jung, W.-H., Yang, B., Yeung, E., Ong, C. S., Chen, Y., Gerecht, S. Hibino, N. (2019) Early Vascular Cells Improve Microvascularization within 3D Cardiac Spheroids. Tissue Eng. Part C: Methods. ten.TEC.2019.0228 https://doi.org/10.1089/ten.TEC.2019.0228
Park, S., Joo Y. K., Chen, Y. (2019) Versatile and High-throughput Force Measurement Platform for Dorsal Cell Mechanics. Scientific Reports. 9, 13286. https://www.nature.com/articles/s41598-019-49592-1
Jung, W.-H., Elawad, K., Kang, S. H., Chen, Y. (2019) Cell–Cell Adhesion and Myosin Activity Regulate Cortical Actin Assembly in Mammary Gland Epithelium on Concaved Surface. Cells. 8(8), 813; https://doi.org/10.3390/cells8080813
Zinn, A., Goicoechea, S. M., Kreider-Letterman, G., Maity, D., Awadia, S., Cedeno-Rosario, L., Chen, Y. & Garcia-Mata, R. (2019) The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly. Sci. Rep. 9, 5163. https://doi.org/10.1038/s41598-019-41558-7
Park, S., Tao, J., Sun, L., Fan, C.-M., Chen, Y. (2019). Economic, Modular and Portable Skin Viscoelasticity Measurement Device for in situ Longitudinal Studies. Molecules. 24 (5): 907. https://doi.org/10.3390/molecules24050907
Sao, K., Jones, T., Doyle, A., Maity, D., Schevzov, G., Chen, Y., Gunning, P., Petrie, R. (2019). Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms. Molecular Biology of the Cell. E18-06-0355. https://doi.org/10.1091/mbc.E18-06-0355
Maity, D., Li, Y., Chen, Y., and Sun, S.X. (2019). Response of collagen matrices under pressure and hydraulic resistance in hydrogels. Soft Matter. 15 (12), 2617. https://doi.org/10.1039/C8SM02143K
Park, S., Lui, C., Jung, W.-H., Maity, D., Ong, C. S., Bush, J., Maruthamuthu, V., Hibino, N., Chen, Y. (2018). Mechanical characterization of hiPSCs-derived cardiac tissues for quality control. Advanced Biosystems. 2(12): 1800251. https://doi.org/10.1002/adbi.201800251
Park, S., Joo Y. K., Chen, Y. (2018). Dynamic adhesion characterization of cancer cells under blood flow-mimetic conditions: effects of cell shape and orientation on drag force. Microfluidics and Nanofluidics. 22: 108. https://doi.org/10.1007/s10404-018-2132-7
Hipp, J. D., Johann, D. J., Chen, Y., Madabhushi, A., Monaco, J., Cheng, J., Rodriguez-Canales, Jaime Stumpe, M. C., Riedlinger, G., Rosenberg, A. Z., Hanson, J. C., Kunju, L. P., Emmert-Buck, M. R. (2018) Computer Aided Laser Dissection (CALD): A Microdissection Workflow Leveraging Image Analysis Tools. J. Pathol. Inform. 9 (1), 45. https://doi.org/10.4103/jpi.jpi_60_18
Pittman, M., Chen, Y. (2018). 3D-printed magnetic tweezers for dorsal traction force measurement. Biotechniques. 65 (6), 347. https://doi.org/10.2144/btn-2018-0078
Mather, I. H., Masedunskas, A., Chen, Y., Weigert R. (2018). Intravital imaging of the lactating mammary gland in live mice reveals novel aspects of milk-lipid secretion. J. Dairy. Sci. 102 (3), 2760. https://doi.org/10.3168/jds.2018-15459
Milberg, O., Shitara, A., Ebrahim, S., Masedunskas, A., Tora, M., Tran, D.T., Chen, Y., Conti, M.A., Adelstein, R.S., Ten Hagen, K.G., et al. (2017). Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals. J. Cell Biol. 216 (7), 1925. https://doi.org/10.1083/jcb.201612126
Masedunskas,
A., Chen, Y., Stussman, R., Weigert, R, Mather, I. H. (2017). Cellular Kinetics of milk lipid droplet (LD) transport, growth and secretion revealed by intravital imaging: LD release is intermittently stimulated by oxytocin. Mol. Biol. Cell. E16-11-0776. https://doi.org/10.1091/mbc.e16-11-0776
(see https://ccr.cancer.gov/node/18445 for more details)
Rosenberg, A.Z., Armani, M.D., Fetsch, P.A., Xi, L., Pham, T.T., Raffeld, M., Chen, Y., O’Flaherty, N., Stussman, R., Blackler, A.R., et al. (2016). High-Throughput Microdissection for Next-Generation Sequencing. PLoS One 11, e0151775. https://doi.org/10.1371/journal.pone.0151775
Porat-Shliom, N., Chen, Y., Tora, M., Shitara, A., Masedunskas, A., and Weigert, R. (2014). In Vivo Tissue-wide Synchronization of Mitochondrial Metabolic Oscillations. Cell Rep. 9, 514–521. https://doi.org/10.1016/j.celrep.2014.09.022
Chen, Y., Pasapera, A.M., Koretsky, A.P., and Waterman, C.M. (2013). Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover. Proc. Natl. Acad. Sci. 110, E2352–E2361. https://doi.org/10.1073/pnas.1221637110
Chen, Y., Dodd, S.J., Tangrea, M.A., Emmert-Buck, M.R., and Koretsky, A.P. (2013). Measuring collective cell movement and extracellular matrix interactions using magnetic resonance imaging. Sci. Rep. 3, 1879. https://doi.org/10.1038/srep01879
Qian, C., Yu, X., Chen, D.-Y., Dodd, S., Bouraoud, N., Pothayee, N., Chen, Y., Beeman, S., Bennett, K., Murphy-Boesch, J., et al. (2013). Wireless Amplified Nuclear MR Detector (WAND) for High-Spatial-Resolution MR Imaging of Internal Organs: Preclinical Demonstration in a Rodent Model. Radiology 268, 228–236. https://doi.org/10.1148/radiol.13121352
Chen, Y., Guzik, S., Sumner, J.P., Moreland, J., and Koretsky, A.P. (2011). Magnetic manipulation of actin orientation, polymerization, and gliding on myosin using superparamagnetic iron oxide particles. Nanotechnology 22, 065101. https://doi.org/10.1088/0957-4484/22/6/065101
Chen, Y., Veracini, L., Benistant, C., and Jacobson, K. (2009). The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton. J. Cell Sci. 122, 3966–3972.
Thelin, W.R., Chen, Y., Gentzsch, M., Kreda, S.M., Sallee, J.L., Scarlett, C.O., Borchers, C.H., Jacobson, K., Stutts, M.J., and Milgram, S.L. (2007). Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J. Clin. Invest. 117, 364–374.
Chen, Y., Lagerholm, B.C., Yang, B., and Jacobson, K. (2006). Methods to measure the lateral diffusion of membrane lipids and proteins. Methods 39, 147–153.
Chen, Y., Thelin, W.R., Yang, B., Milgram, S.L., and Jacobson, K. (2006). Transient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides. J. Cell Biol. 175, 169–178
Peterson, L.J., Rajfur, Z., Maddox, A.S., Freel, C.D., Chen, Y., Edlund, M., Otey, C., and Burridge, K. (2004). Simultaneous stretching and contraction of stress fibers in vivo. Mol. Biol. Cell 15, 3497–3508.
Chen, Y., Yang, B., and Jacobson, K. (2004). Transient confinement zones: a type of lipid raft? Lipids 39, 1115–1119.
Chen, Y., and Lai, M.Z. (2001). c-Jun NH2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells. J. Biol. Chem. 276, 8350–8357.