Park, S., Chen, Y., Mechanics of Biological Systems: Introduction to Mechanobiology and Experimental Techniques.  Morgan & Claypool Publishers.



Peer-Reviewed Journal 

Kaiyrbekov, K., Endresen, K., Sullivan, K., Zheng, Z., Chen, Y., Serra, F. & Camley, B. A. Migration and division in cell monolayers on substrates with topological defects. (2023) Proc. Natl. Acad. Sci. 120.

Liang, L., Zheng, P., Jia, S., Ray, K., Chen, Y. & Barman, I. Plasmonic Nanodiamonds. (2023) Nano Lett. 23, 5746–5754.

Adler, F. R., Anderson, A. R. A., Bhushan, A., Bogdan, P., Bravo-Cordero, J. J., Brock, A., Chen, Y., Cukierman, E., DelGiorno, K. E., Denis, G. V., Ferrall-Fairbanks, M. C., Gartner, Z. J., Germain, R. N., Gordon, D. M., Hunter, G., Jolly, M. K., Karacosta, L. G., Mythreye, K., Katira, P., Kulkarni, R. P., Kutys, M. L., Lander, A. D., Laughney, A. M., Levine, H., Lou, E., Lowenstein, P. R., Masters, K. S., Pe’er, D., Peyton, S. R., Platt, M. O., Purvis, J. E., Quon, G., Richer, J. K., Riddle, N. C., Rodriguez, A., Snyder, J. C., Lee Szeto, G., Tomlin, C. J., Yanai, I., Zervantonakis, I. K. & Dueck, H. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. (2023) Cell Systems 14, 252–257.

Chen, J., Yan, D. & Chen, Y. Understanding the Driving Force for Cell Migration Plasticity. (2023) Biophys. J.

Pittman, M., Ali, A. M., & Chen, Y.. How sticky? How tight? How hot? (2022) Imaging probes for fluid viscosity, membrane tension and temperature measurements at the cellular level. The International Journal of Biochemistry & Cell Biology, 106329.

Afthinos, A., Bera, K., Chen, J., Ozcelikkale, A., Amitrano, A., Choudhury, M. I., Huang, R., Pachidis, P., Mistriotis, P., Chen, Y.* & Konstantopoulos, K.* (2022) Migration and 3D Traction Force Measurements inside Compliant Microchannels. Nano Lett. 22(18), 7318

Huang, P., Illei, P. B., Franklin, W., Wu, P.-H., Forde, P. M., Ashrafinia, S., Hu, C., Khan, H., Vadvala, H. V., Shih, I.-M., Battafarano, R. J., Jacobs, M. A., Kong, X., Lewis, J., Yan, R., Chen, Y., Housseau, F., Rahmim, A., Fishman, E. K., Ettinger, D. S., Pienta, K. J., Wirtz, D., Brock, M. V., Lam, S. & Gabrielson, E. (2022) Lung Cancer Recurrence Risk Prediction through Integrated Deep Learning Evaluation. Cancers . 14, 4150

Flournoy, J., Ashkanani, S. & Chen, Y. (2022). Mechanical regulation of signal transduction in angiogenesis. Front. Cell Dev. Biol. 10

Pittman, M., Iu, E., Li, K., Wang, M., Chen, J., Taneja, N., Jo, M.H., Park, S., Jung, W-.H., Liang, L., Barman, I., Ha, T., Gaitanaros, S., Liu, J. , Burnette, D., Plotnikov, S. Chen, Y. (2022) Membrane Ruffling is a Mechanosensor of Extracellular Fluid Viscosity. Nature Physics. 18(9), 1112

Chen, J. & Chen, Y. (2021) Parametric comparison between sparsity-based and deep learning-based image reconstruction of super-resolution fluorescence microscopy.  Biomed. Opt. Express. 12, 5246.

Park, Y., Jung, J.-G., Yu, Z.-C., Asaka, R., Shen, W., Wang, Y., Jung, W.-H., Tomaszewski, A., Shimberg, G., Chen, Y., Parimi, V., Gaillard, S., Shih, I.-M. & Wang, T.-L. (2021) A Novel Human Endometrial Epithelial Cell Line for Modeling Gynecological Diseases and for Drug Screening. Lab. Investig.

Paria, D., Convertino, A., Raj, P., Glunde, K., Chen, Y. & Barman, I. (2021) Nanowire Assisted Mechanotyping of Cellular Metastatic Potential. Adv. Funct. Mater. 2101638

Wang, G., Sweren, E., Liu, H., Wier, E., Alphonse, M. P., Chen, R., Islam, N., Li, A., Xue, Y., Chen, J., Park, S., Chen, Y., Lee, S., Wang, Y., Wang, S., Archer, N. K., Andrews, W., Kane, M. A., Dare, E., Reddy, S. K., Hu, Z., Grice, E. A., Miller, L. S. & Garza, L. A. (2021) Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe. 29, 777

Lui, C., Chin, A. F., Park, S., Yeung, E., Kwon, C., Tomaselli, G., Chen, Y. & Hibino, N. (2021) Mechanical Stimulation Enhances Development of Scaffold‐Free, 3D‐Printed, Engineered Heart Tissue Grafts. J. Tissue Eng. Regen. Med. term.3188.

Endresen, K. D., Kim, M., Pittman, M., Chen, Y. & Serra, F. (2021) Topological defects of integer charge in cell monolayers. Soft Matter. 17, 5878

Jung, W.-H., Chen, E., Veneziano, R., Gaitanaros, S.*, Chen, Y.* (2020) Stretching DNA Origami: Effect of Nicks and Holliday Junctions on the Axial Stiffness.  Nucleic Acids Research. 48(21):12407

Park, S.#, Jung, W.-H. #, Pittman, M. #, Chen, J. & Chen, Y.  (2020) The Effects of Stiffness, Viscosity, and Geometry of Microenvironment in Homeostasis, Aging and Diseases. J. Biomech. Eng. 142, 10

Park, S., Shi, Y., Kim, B. C., Jo, M. H., Cruz, L. O., Gou, Z., Ha, T., Lu, L.-F., Reich, D. H. & Chen, Y. (2020) Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation. Biosens. Bioelectron. 112389. 

Liu, Z., Lee, S. J., Park, S., Konstantopoulos, K., Glunde, K., Chen, Y. * & Barman, I. * (2020) Cancer cells display increased migration and deformability in pace with metastatic progression. FASEB J.  34, 9307

Orrego, S., Chen, Z., Krekora, U., Hou, D., Jeon. S.-Y., Montoya, C. , Chen, Y., Kang, S. H. (2020) Bioinspired Materials with Self-Adaptable Mechanical Properties. Advanced Materials. 32, 1906970 .

Jung, W.-H., Yam, N., Chen, C.-C., Elawad, K., Hu, B. Chen, Y.  (2020) Force-Dependent Extracellular Matrix Remodeling by Early-Stage Cancer Cells Alters Diffusion and Induces Carcinoma-Associated Fibroblasts. Biomaterials. 234, 119756 .

Pitaktong, I., Lui, C., Lowenthal, J., Mattson, G., Jung, W.-H., Yang, B., Yeung, E., Ong, C. S., Chen, Y., Gerecht, S. Hibino, N. (2019) Early Vascular Cells Improve Microvascularization within 3D Cardiac Spheroids. Tissue Eng. Part C: Methods.  ten.TEC.2019.0228

Park, S., Joo Y. K., Chen, Y. (2019) Versatile and High-throughput Force Measurement Platform for Dorsal Cell Mechanics. Scientific Reports. 9, 13286.

Jung, W.-H., Elawad, K., Kang, S. H., Chen, Y. (2019) Cell–Cell Adhesion and Myosin Activity Regulate Cortical Actin Assembly in Mammary Gland Epithelium on Concaved Surface. Cells. 8(8), 813;

Zinn, A., Goicoechea, S. M., Kreider-Letterman, G., Maity, D., Awadia, S., Cedeno-Rosario, L., Chen, Y. & Garcia-Mata, R. (2019) The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly. Sci. Rep. 9, 5163. 

Park, S., Tao, J., Sun, L., Fan, C.-M., Chen, Y. (2019). Economic, Modular and Portable Skin Viscoelasticity Measurement Device for in situ Longitudinal Studies. Molecules.  24 (5): 907.

Sao, K., Jones, T., Doyle, A., Maity, D., Schevzov, G., Chen, Y., Gunning, P., Petrie, R. (2019).  Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms. Molecular Biology of the Cell.  E18-06-0355.

Maity, D., Li, Y., Chen, Y., and Sun, S.X. (2019). Response of collagen matrices under pressure and hydraulic resistance in hydrogels. Soft Matter. 15 (12), 2617.

Park, S., Lui, C., Jung, W.-H., Maity, D., Ong, C. S., Bush, J., Maruthamuthu, V., Hibino, N., Chen, Y. (2018). Mechanical characterization of hiPSCs-derived cardiac tissues for quality control. Advanced Biosystems. 2(12):  1800251.

Park, S., Joo Y. K., Chen, Y. (2018). Dynamic adhesion characterization of cancer cells under blood flow-mimetic conditions: effects of cell shape and orientation on drag force. Microfluidics and Nanofluidics. 22: 108.

Hipp, J. D., Johann, D. J., Chen, Y., Madabhushi, A., Monaco, J., Cheng, J., Rodriguez-Canales, Jaime Stumpe, M. C., Riedlinger, G., Rosenberg, A. Z., Hanson, J. C., Kunju, L. P., Emmert-Buck, M. R.  (2018) Computer Aided Laser Dissection (CALD): A Microdissection Workflow Leveraging Image Analysis Tools. J. Pathol. Inform. 9 (1), 45.

Pittman, M., Chen, Y. (2018). 3D-printed magnetic tweezers for dorsal traction force measurement. Biotechniques. 65 (6), 347.

Mather, I. H., Masedunskas, A., Chen, Y., Weigert R. (2018). Intravital imaging of the lactating mammary gland in live mice reveals novel aspects of milk-lipid secretion. J. Dairy. Sci.  102 (3), 2760.

Milberg, O., Shitara, A., Ebrahim, S., Masedunskas, A., Tora, M., Tran, D.T., Chen, Y., Conti, M.A., Adelstein, R.S., Ten Hagen, K.G., et al. (2017). Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals. J. Cell Biol. 216 (7), 1925.

Masedunskas, A., Chen, Y., Stussman, R., Weigert, R, Mather, I. H. (2017). Cellular Kinetics of milk lipid droplet (LD) transport, growth and secretion revealed by intravital imaging: LD release is intermittently stimulated by oxytocin. Mol. Biol. Cell. E16-11-0776.

(see for more details)

Rosenberg, A.Z., Armani, M.D., Fetsch, P.A., Xi, L., Pham, T.T., Raffeld, M., Chen, Y., O’Flaherty, N., Stussman, R., Blackler, A.R., et al. (2016). High-Throughput Microdissection for Next-Generation Sequencing. PLoS One 11, e0151775.

Porat-Shliom, N., Chen, Y., Tora, M., Shitara, A., Masedunskas, A., and Weigert, R. (2014). In Vivo Tissue-wide Synchronization of Mitochondrial Metabolic Oscillations. Cell Rep. 9, 514–521.

Chen, Y., Pasapera, A.M., Koretsky, A.P., and Waterman, C.M. (2013). Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover. Proc. Natl. Acad. Sci. 110, E2352–E2361.

Chen, Y., Dodd, S.J., Tangrea, M.A., Emmert-Buck, M.R., and Koretsky, A.P. (2013). Measuring collective cell movement and extracellular matrix interactions using magnetic resonance imaging. Sci. Rep. 3, 1879.

Qian, C., Yu, X., Chen, D.-Y., Dodd, S., Bouraoud, N., Pothayee, N., Chen, Y., Beeman, S., Bennett, K., Murphy-Boesch, J., et al. (2013). Wireless Amplified Nuclear MR Detector (WAND) for High-Spatial-Resolution MR Imaging of Internal Organs: Preclinical Demonstration in a Rodent Model. Radiology 268, 228–236.

Chen, Y., Guzik, S., Sumner, J.P., Moreland, J., and Koretsky, A.P. (2011). Magnetic manipulation of actin orientation, polymerization, and gliding on myosin using superparamagnetic iron oxide particles. Nanotechnology 22, 065101.

Chen, Y., Veracini, L., Benistant, C., and Jacobson, K. (2009). The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton. J. Cell Sci. 122, 3966–3972.

Thelin, W.R., Chen, Y., Gentzsch, M., Kreda, S.M., Sallee, J.L., Scarlett, C.O., Borchers, C.H., Jacobson, K., Stutts, M.J., and Milgram, S.L. (2007). Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J. Clin. Invest. 117, 364–374.

Chen, Y., Lagerholm, B.C., Yang, B., and Jacobson, K. (2006). Methods to measure the lateral diffusion of membrane lipids and proteins. Methods 39, 147–153.

Chen, Y., Thelin, W.R., Yang, B., Milgram, S.L., and Jacobson, K. (2006). Transient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides. J. Cell Biol. 175, 169–178

Peterson, L.J., Rajfur, Z., Maddox, A.S., Freel, C.D., Chen, Y., Edlund, M., Otey, C., and Burridge, K. (2004). Simultaneous stretching and contraction of stress fibers in vivo. Mol. Biol. Cell 15, 3497–3508.

Chen, Y., Yang, B., and Jacobson, K. (2004). Transient confinement zones: a type of lipid raft? Lipids 39, 1115–1119.

Chen, Y., and Lai, M.Z. (2001). c-Jun NH2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells. J. Biol. Chem. 276, 8350–8357.